Education
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1998 – PhD in Chemistry, Faculdade de Ciências de Lisboa (FCL) of University of Lisbon, with Doctor Isabel Rego dos Santos.
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1990 – Graduate in Chemistry, Faculdade de Ciências de Lisboa (FCL) of University of Lisbon.
Professional Employment Career
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Since 2000 – Researcher, Instituto Tecnológico e Nuclear (ITN).
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1999-2000
– Research Assistant, Instituto Tecnológico e
Nuclear.
Fellowships and Training
- 1992-1996 – JNICT fellowship, PhD Grant Program Ciência PRAXIS XXI, at ITN with Doctor Isabel Rego
dos Santos.
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07/11-17/12/94
– JNICT/CNRS fellowship at Laboratoire de Synthése Asymetrique, Université de
Paris-Sud, CNRS, France.
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30/11-19/12/93
– JNICT/CNRS fellowship at Laboratoire de Synthése Asymetrique, Université de Paris-Sud, CNRS, France.
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1990-1992 – PEDIP fellowship, at Instituto Ciência e Energia Nuclear (ICEN) with Doctor Pires de Matos.
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1989-1990 – JNICT fellowship (BJI) at Departamento de Tecnologia das Indústrias Alimentares do LNETI, with Drª Maria Manuela Barbosa
and Doctor Maria de Fátima Norberto Frazão.
Membership of Professional Societies
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Member of the Sociedade Portuguesa de Química.
Scientific Specialization
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Inorganic Chemistry of f-elements.
Other Scientific Areas of Research
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Radiopharmaceuticals Development.
Teaching Activities (Lecturer)
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MSc in Química Inorgânica Biomédica - Aplicações em
Diagnóstico e Terapia, Faculdade de Ciências, Universidade de Lisboa/ITN.
COSTD18 WG-Number:D18/0004/00 (2000-2006).
Scientific Works
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PhD Thesis "Complexos de Urânio com Boratos De Tris(Pirazolilo) e Tetraquis(Pirazolilo", FCL-UL (1998).
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17 Original Publications in Refereed
Journals and
5 Proceedings of international.
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38 Communications to National and International
Meetings.
Participation in Projects
- Novel Metal Fragments Potentially Useful for Labeling
with Tc and/or Re Biologically Relevant Molecules, FCT/POCI/QUI/58245/2004
(2005-2008).
- Multicomponent Technetium and Gallium
Metallointercalators for Target Radioterapy, FCT/POCI/QUI/57632/2004
(2005-2008).
- Radiopharmaceuticals for Treatment of Bone Cancer
Pain and/or Therapy Based on Lanthanide Complexes, FCT/POCTI/CBO/35859.
ITN/ITQB (2002-2005).
- Lanthanide Chemistry for Diagnosis and Therapy",
COSTD18 WG-Number:D18/0004/00 (2000-2006).
Selected Publications
- A Novel Tetraazamacrocycle Bearing a Thiol Pendant Arm for Labeling Biomolecules
with Radiolanthanides, S. Lacerda, M. Paula Campello, F. Marques, L. Gano, V. Kubíček, P. Fousková, E.
Toth, I. Santos, J. Chem. Soc., Dalton Trans. in press.
- A quinazoline-derivative DOTA type gallium(III) complex for targeting Epidermal
Growth Factor Receptors: Synthesis, characterization and biological studies, R.Garcia, P. Fouskova, L.
Gano, A. paulo, P. Campello, E. Toth, I Santos, J. Biolo. Inorg. Chem., 14, 2 (2009) 261-271.
- Study of the cyclen derivative 2-[1,4,7,10-tetraazacyclododecan-1-yl]-ethanethiol
and its complexation behaviour towards d-transition metal ions, S. Lacerda, M.P. Campello, I.C. Santos, I.
Santos, R. Delgado, Polyhedron 26, 14 (2007) 3763-3773.
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Radiolanthanide complexes with tetraazamacrocycles bearing methylphosphonate pendant
arms as bone seeking agents, L. Gano, F. Marques, M. P. Campello, M. Balbina, S. Lacerda, I. Santos, Q. J
.Nucl. Med. Mol. Imaging 51 (2007) 6-15.
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Biological evaluation of 153Sm and 166Ho complexes with
tetraazamacrocycles containing methylcarboxylate and/or methylphosphonate pendant arms", F. Marques, L.
Gano, M.P. Campello, S. Lacerda, I. Santos, Radiochim. Acta 95 (2007) 335-341.
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Radiochemichal and biological evaluation of 153Sm and 166Ho
complexes anchored by a novel bis(methylphosphonate) tetraazamacrocycles", M.P. Campello, F. Marques, L.
Gano, S. Lacerda, I. Santos, Radiochim. Acta, 95 (2007), 329-334.
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13- and 14-membered macrocyclic ligands containing
methylcarboxylate or methylphosphonate pendant arms: chemical and biological
evaluation of their 153Sm and 166Ho complexes as potential agents for
therapy or bone pain palliation, Fernanda Marques, Lurdes Gano, M. Paula Campello, Sara Lacerda, and Isabel Santos*, Luís M. P. Lima, Judite Costa
Patrícia Antunes, Rita Delgado, J. Inorg. Biochemistry, 2006, in press.
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A N,N’-diacetate benzodioxotetraazamacrocycle and its
transition metal complexes, Sara Lacerda, Maria Paula Campello, Isabel
C. Santos, Isabel Santos and Rita Delgado, Polyhedron, 2005, 24 451–461.
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153Sm and 166Ho complexes with
Tetraazamacrocycles containing pyridine and Methylcarboxylate or
Methylphosphonate Pendant arms, F. Marques, K. P. Guerra, L. Gano, J.
Costa, M. P. Campello, L. M. P. Lima, R. Delgado, I. Santos, J.Biol. Inorg.
Chem., 2004, 9(7), 859-872.
- Metal complexes of tetraazacyclophane: Solution and molecular modelling studies,
Patrícia Antunes, Paula M. Campello, Rita Delgado, Michael G. B. Drew, Vitor Félix Isabel Santos, J. Chem.
Soc., Dalton Trans., (2003), 1852-1860.
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