Curriculum Vitae

Centro de Ciências e Tecnologias Nucleares (C2TN)


Name: Maria Paula
Surnames: Cabral Campello
Born: 04-08-1961, Lisbon, Portugal
Nationality: Portuguese

Phone: +351 21 994 6233
Fax: +351 21 994 6185
E-mail: pcampelo (@ctn.ist.utl.pt)


Education

  • 1998 – PhD in Chemistry, Faculdade de Ciências de Lisboa (FCL) of University of Lisbon, with Doctor Isabel Rego dos Santos.
  • 1990 – Graduate in Chemistry, Faculdade de Ciências de Lisboa (FCL) of University of Lisbon.

Professional Employment Career

  • Since 2000 – Researcher, Instituto Tecnológico e Nuclear (ITN).
  • 1999-2000 – Research Assistant, Instituto Tecnológico e Nuclear.

Fellowships and Training

  • 1992-1996 – JNICT fellowship, PhD Grant Program Ciência PRAXIS XXI, at ITN with Doctor Isabel Rego dos Santos.
  • 07/11-17/12/94 – JNICT/CNRS fellowship at Laboratoire de Synthése Asymetrique, Université de Paris-Sud, CNRS, France.
  • 30/11-19/12/93 – JNICT/CNRS fellowship at Laboratoire de Synthése Asymetrique, Université de Paris-Sud, CNRS, France.
  • 1990-1992 – PEDIP fellowship, at Instituto Ciência e Energia Nuclear (ICEN) with Doctor Pires de Matos.
  • 1989-1990 – JNICT fellowship (BJI) at Departamento de Tecnologia das Indústrias Alimentares do LNETI, with Drª Maria Manuela Barbosa and Doctor Maria de Fátima Norberto Frazão.

Membership of Professional Societies

  • Member of the Sociedade Portuguesa de Química.

Scientific Specialization

  • Inorganic Chemistry of f-elements.

Other Scientific Areas of Research

  • Radiopharmaceuticals Development.

Teaching Activities (Lecturer)

  • MSc in Química Inorgânica Biomédica - Aplicações em Diagnóstico e Terapia, Faculdade de Ciências, Universidade de Lisboa/ITN. COSTD18 WG-Number:D18/0004/00 (2000-2006).

Scientific Works

  • PhD Thesis "Complexos de Urânio com Boratos De Tris(Pirazolilo) e Tetraquis(Pirazolilo", FCL-UL (1998).
  • 17 Original Publications in Refereed Journals and 5 Proceedings of international.
  • 38 Communications to National and International Meetings.

Participation in Projects

  • Novel Metal Fragments Potentially Useful for Labeling with Tc and/or Re Biologically Relevant Molecules, FCT/POCI/QUI/58245/2004 (2005-2008).
  • Multicomponent Technetium and Gallium Metallointercalators for Target Radioterapy, FCT/POCI/QUI/57632/2004 (2005-2008).
  • Radiopharmaceuticals for Treatment of Bone Cancer Pain and/or Therapy Based on Lanthanide Complexes, FCT/POCTI/CBO/35859. ITN/ITQB (2002-2005). 
  • Lanthanide Chemistry for Diagnosis and Therapy", COSTD18 WG-Number:D18/0004/00 (2000-2006).

Selected Publications

  • Palma E.; Correia J.D.G., Campello M. P. C.; Santos, I. Bisphosphonates as radionuclide carriers for imaging or systemic therapy. Molecular Biosystems, 7, 2950 (2011).
    Journal impact factor: 3.35, Citations: 5.
  • Campello M. P.C.; Lacerda S.; Santos I.C.; et al. Lanthanide(III) Complexes of 4,10-Bis(phosphonomethyl)-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (trans-H(6)do2a2p) in Solution and in the Solid State: Structural Studies Along the Series. Chem.-A Europ. J. , 16, 8446 (2010).
    Journal impact factor: 5.831, Citations: 10.
  • Lacerda S.; Campello M. P.C.; Marques F.; Gano L.; Kubíček V.; Fousková P.; Tóth E.; Santos I. al. A novel tetraazamacrocycle bearing a thiol pendant arm for labeling biomolecules with radiolanthanides. Dalton Transactions , 23, 4509 (2009).
    Journal impact factor: 3.806, Citations: 9.
  • Garcia R.; Fousková P.; Gano L.; Paulo A.; Campello C.; Tóth E. : A quinazoline-derivative DOTA-type gallium(III) complex for targeting epidermal growth factor receptors: synthesis, characterisation and biological studies. Journal of Biological Inorganic Chemistry , 14, 261 (2009).
    Journal impact factor: 3.353, Citations: 7.

Other Publications

  • S. Lacerda, M. Paula Campello, F. Marques, L. Gano, V. Kubíček, P. Fousková, E. Toth, I. Santos,A Novel Tetraazamacrocycle Bearing a Thiol Pendant Arm for Labeling Biomolecules with Radiolanthanides,  J. Chem. Soc., Dalton Trans. in press.
  • R.Garcia, P. Fouskova, L. Gano, A. paulo, P. Campello, E. Toth, I Santos,A quinazoline-derivative DOTA type gallium(III) complex for targeting Epidermal Growth Factor Receptors: Synthesis, characterization and biological studies,  J. Biolo. Inorg. Chem., 14, 2 (2009) 261-271.
  • S. Lacerda, M.P. Campello, I.C. Santos, I. Santos, R. Delgado, Study of the cyclen derivative 2-[1,4,7,10-tetraazacyclododecan-1-yl]-ethanethiol and its complexation behaviour towards d-transition metal ions, Polyhedron 26, 14 (2007) 3763-3773.
  • L. Gano, F. Marques, M. P. Campello, M. Balbina, S. Lacerda, I. Santos, Radiolanthanide complexes with tetraazamacrocycles bearing methylphosphonate pendant arms as bone seeking agents, Q. J. Nucl. Med. Mol. Imaging 51 (2007) 6-15.
  •  F. Marques, L. Gano, M.P. Campello, S. Lacerda, I. Santos, Biological evaluation of 153Sm and 166Ho complexes with tetraazamacrocycles containing methylcarboxylate and/or methylphosphonate pendant arms, Radiochim. Acta 95 (2007) 335-341.
  • M.P. Campello, F. Marques, L. Gano, S. Lacerda, I. Santos, Radiochemichal and biological evaluation of 153Sm and 166Ho complexes anchored by a novel bis(methylphosphonate) tetraazamacrocycles, Radiochim. Acta, 95 (2007), 329-334.
  • Fernanda Marques, Lurdes Gano, M. Paula Campello, Sara Lacerda, and Isabel Santos, Luís M. P. Lima, Judite Costa Patrícia Antunes, Rita Delgado, 13- and 14-membered macrocyclic ligands containing methylcarboxylate or methylphosphonate pendant arms: chemical and biological evaluation of their 153Sm and 166Ho complexes as potential agents for therapy or bone pain palliation, J. Inorg. Biochemistry, 2006, in press.
  • Sara Lacerda, Maria Paula Campello, Isabel C. Santos, Isabel Santos and Rita Delgado, A N,N’-diacetate benzodioxotetraazamacrocycle and its transition metal complexes, Polyhedron, 2005, 24 451–461.
  • F. Marques, K. P. Guerra, L. Gano, J. Costa, M. P. Campello, L. M. P. Lima, R. Delgado, I. Santos, 153Sm and 166Ho complexes with Tetraazamacrocycles containing pyridine and Methylcarboxylate or Methylphosphonate Pendant arms, J.Biol. Inorg. Chem., 2004, 9(7), 859-872.
  • Patrícia Antunes, Paula M. Campello, Rita Delgado, Michael G. B. Drew, Vitor Félix Isabel Santos, Metal complexes of tetraazacyclophane: Solution and molecular modelling studies, J. Chem. Soc., Dalton Trans., (2003), 1852-1860.