Curriculum Vitae

Centro de Ciências e Tecnologias Nucleares (C2TN)


Photo.

Name: João Domingos
Surnames: Galamba Correia
Born: 14-10-1967, Porto-Amélia, Mozambique
Nationality: Portuguese

Phone:  +351 21 994 6233/1455
Fax: +351 21 994 6185
E-mail: jgalamba (add @ctn.ist.utl.pt)

ORCID: http://orcid.org/0000-0002-7847-4906; ResearcherID: J-7036-2013; Scopus Author ID: 7202364104


Education

  • 1998-2000 – FCT/PRAXIS fellowship: Postdoctoral position at the Inorganic and Radiopharmaceutical chemistry group, Department of Chemistry, Instituto Tecnológico e Nuclear, Sacavém, Portugal.
  • 1993-1996 – PhD in Inorganic Chemistry at the Inorganic Chemistry Institute of the Technical University of Munich, Germany, under the Supervision of Prof. Dr. Drs. hc. W. A. Herrmann. Title of the Thesis: Molecular Rhenium Oxides as Oxidation Catalysts.
  • 1985-1991 – Graduation in Pharmaceutical Sciences, Faculdade de Farmácia, Universidade de Lisboa, Portugal.

Professional Employment Career

  • 02/2006 – Principal Researcher, ITN.
  • 2000 – Invited Junior Researcher, Inorganic and Radiopharmaceutical Chemistry Group, Instituto Tecnológico e Nuclear (ITN).
  • 1999 – Pharmaceutical Assessor (Radiopharmaceuticals - Quality), at the National Portuguese Authority for the Evaluation of Medicinal Products (INFARMED).
  • 1996-1997 – Pharmacist at Sanofi-Winthrop, Portugal.

Fellowships and Training

  • 2013 – COST CM-1004 Training School: Chemical probes in chemical proteomics and biosynthesis studies. Universitaet Duisburg-Essen, Campus Essen, Germany (November 11-15, 2013).
  • 2003 STSM (short term scientific mission) at the Division of Radiological Chemistry, Institute of Nuclear Medicine, Department of Radiology, University Hospital, Basel, Switzerland in the group of Prof. H. Maecke - COST ACTION B12. Radiotracers for in vivo assessment of biological functions. Working Group 3: "RADIOLABELLED BIOLOGICALLY ACTIVE PEPTIDES".
  • 2001 STSM (short term scientific mission) at the Institute of Inorganic Chemistry, University of Zurich, Switzerland, in the group of Prof. R. Alberto - COST ACTION B12. Radiotracers for in vivo assessment of biological functions. Working Group 5: "TECHNETIUM CHELATES".
  • 2000 – STSM (short term scientific mission) at the Institute of Inorganic Chemistry, University of Zurich, Switzerland, in the group of Prof. R. Alberto - COST ACTION B12. Radiotracers for in vivo assessment of biological functions. Working Group 5: "TECHNETIUM CHELATES"
  • 1994/1996 – DAAD fellowship at the Inorganic Chemistry Institute of the Technical University of Munich, Germany.
  • 1993 – Four months training at the Inorganic Chemistry Institute of the Technical University of Munich, Germany under the supervision of Prof. Dr. Drs. hc. W. A. Herrmann.
  • 1991/1993 – JNICT fellowship at the Organic Chemistry group of the Instituto de Tecnologia Química e Biológica, Oeiras, Portugal.
  • 1990/1991 – Undergraduate Trainee at the Pfizer laboratories, Portugal.
  • 1988/1990 – INIC undergraduate fellowship at the Centro de Estudos de Ciências Farmacêuticas, Universidade de Lisboa.

Membership of Professional Societies

  • Member of the Ordem dos Farmacêuticos, Portugal.
  • Member of the Sociedade Portuguesa de Medicina Nuclear.

Scientific Specialization

  • Organic Chemistry.
  • Inorganic Chemistry. Homogeneous Oxidation catalysis.

Other Scientific Areas of Research

  • Medicinal Chemistry.
  • Labeling of relevant Biomolecules with 99mTc/Re.
  • Bioinorganic.
  • Synthesis and biological evaluation of peptides.
  • Small-domain antibodies.

Teaching Activities (Lecturer)

  • MSc in Oncobiologia - Faculdade de Medicina, IMM, Universidade de Lisboa.
  • MSc in Química Inorgânica Biomédica - Aplicações em Diagnóstico e Terapia - Faculdade de Ciências, Universidade de Lisboa/ITN.
  • MSc in Química Farmacêutica e Terapêutica - Faculdade de Farmácia, Universidade de Lisboa.

Participation in Projects

  • Principle Investigator: Project PTDC/QUI-QUI/121752/2010 - Nitric Oxide Synthase targeting with Re(I)/99mTc(I)-complexes containing L-Arg derivatives: A structure-activity study. Funded by FCT.
  • Team Member: EXPL/QEQ-MED/1950/2013 - Dual Targeting Strategy for EGFR Positive Tumors. Funded by FCT.
  • Team Member: Project EXPL/BIM-MEC/0115/2012 - A Molecular Imaging Approach to Cystic Fibrosis. Funded by FCT.
  • Team Member: Project EXCL/QEQ-MED/0233/2012 - Molecular and Nano Tools for Cancer Theranostics. Funded by FCT.
  • Member of the Team: Project PTDC/QUI-QUI/115712/2009 - Síntese, Caracterização e Avaliação Biológica de Compostos Multifuncionais Osteotrópicos. ITN/IMM (Faculty of Medicine, University of Lisbon). Funded by FCT.
  • Team Member: PTDC/SAU-FAR/115846/2009 - Peptidos de interacção com a albumina para melhor a farmacocinética das proteinas. ITN/ADEIM (Faculty of Pharmacy, University of Lisbon). Funded by FCT.
  • COST Action CM-1004: Chemical probes in chemical proteomics and biosynthesis studies (MC).
  • COST action TD-1004: Theragnostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery.
  • Principal Investigator: POCI/SAU-FCF/58855/2004: Radiolabeling of L-Arginine Analogues with the Unit fac-[99mTc(CO)3]+ for Probing Nitric Oxide Synthase (NOS) in vivo: Synthesis, Characterization and Biological Evaluation (2005-2008).
  • Specific Organometallic Complexes, Research Contract Mallinckrodt - Tyco Healthcare (2003-2006).
  • Development of 99mTc based small biomolecules using novel 99mTc Cores, IAEA project (2002-2005).
  • COST B12: Radiotracers for in vivo Assessment of Biological Functions (1999-2004).

Scientific Works

  • PhD Thesis: "Molecular Rhenium Oxides as Oxidation Catalysts".
  • 5 Original patents.
  • 45 Original publications in Refereed Journals.
  • More than 50 communications (22 oral that 35 posters) in national and international conferences.

4 Selected Publications

  • Maurício Morais, Paula D. Raposinho, Maria C. Oliveira, David Pantoja-Uceda, Maria A. Jimenez, Isabel Santos, João D. G. Correia, NMR Structural Analysis of MC1R-Targeted Rhenium(I) Metallopeptides and Biological Evaluation of 99mTc(I) Congeners, Organometallics 2012, 31, 5929.

  • Journal impact factor:  4.145, Citations: 1.
  • João D. G. Correia, A. Paulo, Paula D. Raposinho, Isabel Santos, Radiometallated peptides for molecular imaging and targeted therapy, Dalton Trans. 2011, 40, 6144,
    Journal impact factor:  3.806; Citations: 21.
  • B. L. Oliveira, P. D. Raposinho, F. Mendes, F. Figueira, I. Santos, A. Ferreira, C. Cordeiro, A. P. Freire, J. D. G. Correia, Re and Tc Tricarbonyl Complexes: From the Suppression of NO Biosynthesis in Macrophages to in Vivo Targeting of iNOS, Bioconjugate Chem. 2010, 21, 2168.
    Journal impact factor:  4.580; Citations: 5.
  • Paula D. Raposinho, Catarina Xavier, João D. G. Correia, Soraia Falcão, Paula Gomes, Isabel Santos, Melanoma targeting with alpha-MSH analogs labeled with fac-[99mTc(CO)3]+: effect of cyclization on tumor-seeking properties, J. Biol. Inorg. Chem. 2008, 13, 449.
    Journal impact factor:  3.353; Citations: 29.

Other Publications

  • Comparative biological evaluation of two [99mTc(CO)3]-dextran pyrazolyl mannose conjugates developed for use in sentinel lymph node detection, S. Subramanian, U. Pandey, M. Morais, J. D. G. Correia, I. Santos, G. Samuel, Q. J. Nucl. Med. 2013, in press.
  • Emerging protein targets for metal-based pharmaceutical agents: An update, A. de Almeida, B. L. Oliveira, J. D. G. Correia, G. Soveral, A. Casini, Coord. Chem. Rev. 2013, 257, 19–20, 2689-2704.
  • Influence of the Bifunctional Chelator on the Pharmacokinetic Properties of 99mTc(CO)3-labeled cyclic a-Melanocyte Stimulating Hormone, M. Morais, B. L. Oliveira, J. D. G. Correia, M. C. Oliveira, M. A. Jiménez, I Santos, P. D. Raposinho, J. Med. Chem. 2013, 56, 1961-1973.
  • Theoretical studies on the binding of rhenium(I) complexes to inducible nitric oxide synthase Original Research Article, Bruno L. Oliveira, I. S. Moreira, P. A. Fernandes, M. J. Ramos, I. Santos, J. D. G. Correia, J. Mol. Graph. Modelling 2013, 45, 13-25.
  • Target-specific Tc(CO)3-complexes for in vivo imaging, Maurício Morais, António Paulo, Lurdes Gano, Isabel Santos, João D.G. Correia, J. Organomet. Chem. 2013, 125-139.
  • Evaluation of novel 99mTc(I)-labeled homobivalent a-melanocyte-stimulating hormone analogs for melanocortin-1 receptor targeting, M. Morais, P. D. Raposinho, M. C. Oliveira, J. D. G. Correia, I. Santos, J. Biol. Inorg. Chem. 2012, 17, 491-505.
  • Mannosylated dextran derivatives labeled with fac-[M(CO)3]+ (M = 99mTc, Re) for specific targeting of sentinel lymph node. M. Morais, S. Subramanian, U. Pandey, G. Samuel, M. Venkatesh, M. Martins, S. M. S. Pereira, J. D. G. Correia, I. R. Santos, Mol. Pharmaceutics 2011, Mol. Pharmaceutics 2011, 8, 609–620.

Original Patents

  • Bifunctional Tridentate Pyrazolyl Containing Ligands for Re and Tc Tricarbonyl complexes, I. Santos, J. D. G. Correia, A. Paulo, S. Alves, R. Vitor, WO 2004/091669 A1, 2004-10-28.
  • Process for the selective oxidation of aromatic compounds, W. A. Herrmann, J. D. G. Correia, R. W. Fischer, US 5,710,292, 1998-01-20.
  • Process for the catalytic oxidation of aromatic compounds, W. A. Herrmann, J. D. G. Correia, R. W. Fischer, W. Adam, J. Lin, C. R. Saha-Möller, M. Shimizu, US 5,616,734, 1997-04-01.
  • Verfahren zur katalytischen Oxidation von Aromatischen Verbindungen, W. A. Herrmann, J. D. G. Correia, R. W. Fischer, W. Adam, J. Lin, C. R. Saha-Möller, M. Shimizu, EP 0 665 209 A1, 1995-01-24.
  • Verfahren zur selektiven Oxidation aromatischer Verbindungen, W. A. Herrmann, J. D. G. Correia, R. W. Fischer, EP 0 686 618 A1, 1995-05-26.
  • Verfahren zur katalytischen Oxidation von Aromatischen Verbindungen, W. A. Herrmann, J. D. G. Correia, R. W. Fischer, W. Adam, J. Lin, C. R. Saha-Möller, M. Shimizu, DE 44 19 799 A1, 1995-12-07.