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CURRICULUM VITAE

Photo.

Name: Isabel
Surnames: Rego Santos
Born: Portimão, Portugal
Nationality: Portuguese

Phone: +351-21 994 6201 (6243/6191/6193)
Fax: +351-21-994 6185
E-mail: isantos (@itn.pt)

Education

  • Professor Degree, Technical University of Lisbon, Portugal.
  • PhD, Chemistry, Technical University of Lisbon, Portugal.
  • Graduation in Chemical Engineering, Technical University of Lisbon, Portugal.
  • BSc in Chemistry, Instituto Industrial de Lisboa, Portugal.

Professional Employment Career

  • Investigador Principal (Senior Researcher) and Group Leader, ITN, Sacavém, Portugal.

Fellowships and Training

  • JNICT/CNRS – Laboratoire de Synthèse Asymétrique, Université de Paris-Sud, CNRS, France.
  • NATO – Fundamental and Technological Aspects of Organo-f-element Chemistry, NATO Advanced Study Institute.
  • IAEA fellowship at the Endocrinology Department, Middlesex Hospital, London.
  • IAEA fellowship for the Interregional Training Course on the preparation and Control of Radiopharmaceuticals.

Membership of Professional Societies

  • Member of the Sociedade Portuguesa de Química.
  • Member of the Sociedade Portuguesa de Medicina Nuclear.
  • Member of the European Association of Nuclear Medicine.

Scientific Specialization

  • Inorganic and Organometallic Chemistry of  f-and d-elements, Radiochemistry and Radiopharmacy.

Main Scientific Area of Research

  • The main scientific activity of Isabel Santos is in inorganic and organometallic chemistry of d- and f-transition metals and in radiochemistry. She has been studying mainly d- and f-transition metal - based drugs potentially interesting for medical applications, namely for diagnostic and/or therapy.
  • She is the leader of the Radiopharmaceutical Sciences Group, Unit of Chemistry Department, ITN.
  • She has mentored 6 Graduation Thesis, has supervised the work of 6 BIC fellows, has mentored 1 Master student, and 6 PhD students and has supervised the work of 6 Post-doctoral fellows.
  • She has organized, coordinates and teaches, in collaboration with the University of Lisbon and some Hospitals of Lisbon, a Master Course ″Biomedical Inorganic Chemistry: Diagnostic and Therapeutical Applications″ (DR nº 123, 26/05/04, II série). First Edition 2004-2005; Second Edition 2005/2006; Third Edition 2006/2007.
  • She has also organized some courses for Physicians Resident in Nuclear Medicine, which are supported by her group (Portaria 55572003, 11 June).
  • Isabel Santos has also been invited for teaching in Post-Graduation Courses organized by other Universities and Associated Laboratories
Scientific Works

  • PhD Thesis "Uranium (IV) and (III) Complexes with Poly(pyrazolyl)borates", IST-Technical University of Lisbon, Portugal.
  • Author or co-author of 100 original publications in Refereed Journals, of which 4 invited Reviews.
  • 2 Chapters in books.
  • 4 International and European patents.
  • One hundred lectures, oral presentations and communications to national and international meetings.
Selected Publications
  • 99mTc(CO)3-pyrazolyl conjugates of RGD: in vitro and in vivo evaluation of [99mTcL(CO)3-cyclo[Arg-Gly-Asp-D-Tyr-Lys]] (L = tridentate pyrazolyl-based chelating ligand framework), S. Alves, J.D.G. Correia, L. Rold, A. Prasanphanich, R. Haubner, M. Rupprich, E. von Guggenberg, R. Alberto, C. Decristoforo, I. Santos, C. J. Smith, Bioconjugate Chem. DOI 10.1021/bc060234t.
  • Very Small and Soft Scorpionates: Water Stable Technetium Tricarbonyl Complexes Combining a Bis-agostic (k3-H, H, S) Binding Motif with Pendant and Integrated Bioactive Molecules, L. Maria, A. Paulo, I. C. Santos, P. Kurz, B. Spingler, R Alberto, I. Santos, J. Am. Chem. Soc. 128 (2006) 14590-14598. 
  • Pyrazolyl Containing Ligands as Bifunctional Chelators for Labelling Biomolecules with the fac-[M(CO)3]+ Moiety (M=99mTc, Re): Synthesis, S. Alves, J. D. G. Correia, A. Paulo, L. Gano, J. Smith, I. Santos, Characterization and Biological Behaviour, Bioconjugate Chemistry 16 (2005) 438.
  •  Synthesis and Structural Studies of Rhenium(V) Complexes Stabilized by a Monoanionic Cyclen Ligand, C. Xavier, A. Paulo, A. Domingos, I. Santos, European Journal of Inorg. Chem. (2004) 243. (cover picture)
  •  153Sm and 166Ho Complexes with Tetraaza Macrocycles Containing Pyridine and Methylcarboxylate or Methylphosphonate Pendant Arms, F. Marques, K. P. Guerra, L. Gano, J. Costa, M. P. Campello, L. M. P. Lima, R. Delgado, I. Santos, J. of Biological Inorganic Chemistry 9 (2004) 859.
  • Synthesis and Structural Characterization of Novel Re(I) Tricarbonyl Complexes Anchored on a Phosphinoarylbenzylamine and a Phosphinoaryl-oxazoline Generated in situ, T. Kniess, J. D. G. Correia, Â. Domingos, E. Palma, I. Santos,  Inorg. Chem. 42 (2003) 6130.
  • Reactivity of [Re{k3-H(m-H)B(timMe)2}(CO)3] towards neutral substrates, R. Garcia, A. Paulo, A. Domingos, I. Santos, Inorg. Chem. 41 (2002) 2422.
  •  Re and Tc Complexes Containing B-H…M Agostic Interactions as Building Blocks for the Design of Radiopharmaceuticals, Garcia, R., Paulo, A., Domingos, A., Santos, I., Ortner, K., Alberto, R., J. Am. Chem. Soc. 122 (2000) 11240.

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