Curriculum Vitae

Centro de Ciências e Tecnologias Nucleares (C2TN)


Photo

Name: Isabel
Surnames: Rego dos Santos
Born: Portimão, Portugal
Nationality: Portuguese

Phone: +351 21 994 6201 (6243/6191/6193)
Fax: +351 21 994 6185
E-mail: isantos (add @itn.pt) and idsantos@fc.ul.pt


Education

  • Professor Degree, Technical University of Lisbon, Portugal.
  • PhD, Chemistry, Technical University of Lisbon, Portugal.
  • Graduation in Chemical Engineering, Technical University of Lisbon, Portugal.
  • BSc in Chemistry, Instituto Industrial de Lisboa, Portugal.

Professional Employment Career

  • Senior Coordinating Researcher, C2TN, IST, Universidade Lisboa, Portugal.
  • President of "Centro de Ciências e Tecnologias Nucleares" (C2TN) IST, Universidade de Lisboa.
  • Leader of the Radiopharmaceutical Sciences (CR), C2TN, IST, Universidade Lisboa, Portugal.
  • Professor at Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal.

Fellowships and Training

  • JNICT/CNRS – Laboratoire de Synthèse Asymétrique, Université de Paris-Sud, CNRS, France.
  • NATO – Fundamental and Technological Aspects of Organo-f-element Chemistry, NATO Advanced Study Institute.
  • IAEA fellowship at the Endocrinology Department, Middlesex Hospital, London.
  • IAEA fellowship for the Interregional Training Course on the preparation and Control of Radiopharmaceuticals.

Membership of Professional Societies

  • Member of the Sociedade Portuguesa de Química.
  • Member of the Sociedade Portuguesa de Medicina Nuclear.
  • Member of the European Association of Nuclear Medicine.

Scientific Specialization

  • Inorganic and Organometallic Chemistry of  d- and f-elements for PET/SPECT Molecular Imaging and Theranostics.

Main Scientific Area of Research

  • Isabel Santos has been studying mainly d- and f-transition metals - based drugs potentially interesting for medical applications, namely for SPECT/PET Molecular Imaging and Theranostics.
  • She has mentored 6 Graduation Thesis, has supervised the work of 11 BIC fellows, has mentored 5 Master students and 16 PhD students and has supervised the work of 9 Post-doctoral fellows.
  • She has organized, coordinated and lectured, in collaboration with the University of Lisbon and some Hospitals of Lisbon, a Master Course ″Biomedical Inorganic Chemistry: Diagnostic and Therapeutical Applications″ (DR nº 123, 26/05/04, II série). First Edition 2004-2005.
  • She has also organized some courses for Physicians Resident in Nuclear Medicine, which are supported by her group (Portaria 55572003, 11 June).
  • Isabel Santos has also been invited for teaching in Post-Graduation Courses organized by other Universities and Associated Laboratories

Scientific Works

  • PhD Thesis "Uranium (IV) and (III) Complexes with Poly(pyrazolyl)borates", IST-Technical University of Lisbon, Portugal.
  • Author or co-author of 190 original publications in Refereed Journals, of which 9 invited Reviews.
  • 4 Chapters in books.
  • 4 International and European patents.
  • Two hundred lectures, from which fifty two invited, eighty one oral presentations and communications to national and international meetings.

Projects (Co-ordinator) in the last few years

  • EXCL/QEQ-MED/0233/2012: Molecular and Nano Tools for Cancer Theranostics, 2013-2016.
  • COST Action CM1105: Functional metal complexes that bind to biomolecules, 2012-2016.
  • Portugal/Spain, E-23/12: Target-specific and Heterobimetallic Complexes: Synthesis, Characterization and Mechanistic Studies, 2012-2014
  • COST Action TD1004: Theranostics Imaging and Therapy: An Action To Develop Novel Nanosized Systems For Imaging-Guided Drug Delivery, 2011-2015.
  • PTDC/QUI-QUI/115712/2009: Synthesis, Characterization and Biological Assessment of Multi-Functional Bone-Seeking Agents, 2011-2014.
  • FCT/DAAD (Processo 44100): Radiosynthesis and Biological Evaluation of Novel Receptor Tyrosine Kinase Inhibitors for in vivo Targeting of EGFR and VEGFR, 2009-2010.
  • IAEA Co-ordinated Research Program, Development of Tc-99m Radiopharmaceuticals for Sentinel Node Detection and Cancer Diagnosis, 2007-2010.
  • GRICES/Academy of Sciences CZECH Republic: "Lanthanide complexes as potential therapeutic agents: Chemistry, radiochemistry and biological studies", 2006-2008.
  • POCI/QUI/58245/2004: New Metal Fragments for Labelling with Tc and/or Re Biologically Interesting Molecules, 2005-2008.
  • IAEA Co-Ordinated Research Program: "Development of Tc-99m Based Small Biomolecules Using Novel Tc99m Cores", 2003-2006.
  • POCTI/35859/SAU/1999: Lanthanide Complexes with Tetraazamacrocycles for Bone Pain Palliation and/or Therapy of Bone Metastasis, 2002-2005.
  • Medical BV, Covidien, St Louis, USA (previous Mallinckrodt): Specific Radiopharmaceuticals, 2003-2009.
  • POCTI/35423/1999/QUI: Re and Tc Complexes for Peptide - Based Specific Radiopharmaceuticals: Chemistry, Radiochemistry and in vitro/in vivo Biological Studies, 2000-2003.

Selected Publications

  • D. Can, B. Spingler, P. Schmutz, F. Mendes, P. Raposinho, C. Fernandes, F. Carta, A. Innocenti, I. Santos, C. Supuran, R. Alberto, [(Cp-R)M(CO)3] (M = Re or 99mTc) Sulphonamide Conjugates for Selective Targeting of Human Carbonic Anhydrase IX, Angewandte Chemie, 51 (2012) 3354–3357.
    Journal impact factor: 13.734, Citations: 11.
  • M. Morais, S. Subramanian, M. Martins, U. Pandey, G. Samuel, S. Pereira, M. Venkatesh, João D. G. Correia, Isabel Santos, Mannosylated Dextran Derivatives Labeled with fac-[M(CO)3]+ (M = 99mTc, Re) for Specific Targeting of Sentinel Lymph Node, Mol. Pharmaceutics 8 (2011) 609-620.
    Journal impact factor: 4.570, Citations: 6.
  • F. Mendes, M. Groessl, A.A. Nazarov, G. Sava, I. Santos, Dyson PJ, A. Casini, Metal-Based Inhibition of Poly(ADP-ribose) Polymerase - The Guardian Angel of DNA J Med Chemistry, 54 (2011) 2196–2206.
    Journal impact factor: 5.614, Citations: 30.
  • M. P. C. Campello, S. Lacerda, I. C. Santos, G. A. Pereira, C. F. G. C. Geraldes, J. Kotek, P. Hermann, J. Vanek, P. Lubal, V. Kubcek, E. Toth, I. Santos, Lanthanide (III) Complexes of 4,10-Bis(phosphonomethyl)-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (trans-H6do2a2p) in Solution and in the Solid State: Structural Studies Along the Series, Chem. Eur. J. 16 (2010) 8446 – 8465.
    Journal impact factor: 5.831, Citations: 10.

Other Publications

  • S. Gama, F. Mendes, T. Esteves, F. Marques, A. Matos, J. Rino, J. Coimbra, M. Ravera, E. Gabano, I. Santos, A. Paulo, Synthesis and biological studies of pyrazolyl-diamine PtII complexes containing polyaromatic DNA-binding groups, ChemBioChem 13, 2352-2362 (2012).
  • G. R. Morais, I. Santos, A. Paulo, Organometallic complexes for SPECT imaging and/or radionuclide therapy, Organometallics, 31, 5693-5714 (2012).
  • M. Morais, P. D. Raposinho, M. C. Oliveira, D. Pantoja-Uceda, M. A. Jimenez, I. Santos, J. D. G. Correia, NMR Structural Analysis of MC1R-Targeted Rhenium(I) Metallopeptides and Biological Evaluation of 99mTc(I) Congeners, Organometallics, 31, 5929-5939 (2012).
  • João D. G. Correia, António Paulo, Paula D. Raposinho and Isabel Santos, Radiometallated peptides for molecular imaging and targeted therapy, Dalton Trans. 40 (2011) 5377- 5393.
  • Elisa Palma, Joâo D. G. Correia, Bruno L. Oliveira, Lurdes Gano, Isabel C. Santos and Isabel Santo, 99mTc(CO)3-Labeled Pamidronate and Alendronate for Bone Imaging, Dalton Trans. 40 (2011) 2787-2796.
  • Teresa Esteves, Catarina Xavier, Sofia Gama, Filipa Mendes, Paula D. Raposinho, Fernanda Marques, António Paulo, João Costa Pessoa, José Rino, Giampietro Viola, Isabel Santos, Tricarbonyl M (I) (M = Re, 99mTc) Complexes Bearing Acridine Fluorophores: Synthesis, Characterization, DNA Interaction Studies and Nuclear Targeting, Organic and Biomolecular Chemistry 8 (2010) 4104–4116. 
  • L. Maria, A. Paulo, I. C. Santos, P. Kurz, B. Spingler, R Alberto, I. Santos, Very Small and Soft Scorpionates: Water Stable Technetium Tricarbonyl Complexes Combining a Bis-agostic (k3-H, H, S) Binding Motif with Pendant and Integrated Bioactive Molecules, J. Am. Chem. Soc. 128 (2006) 14590-14598. 
  • S. Alves, J. D. G. Correia, A. Paulo, L. Gano, J. Smith, I. Santos, Characterization and Biological Behaviour, Pyrazolyl Containing Ligands as Bifunctional Chelators for Labelling Biomolecules with the fac-[M(CO)3]+Moiety (M=99mTc, Re): Synthesis, Bioconjugate Chemistry 16 (2005) 438.
  • C. Xavier, A. Paulo, A. Domingos, I. Santos, Synthesis and Structural Studies of Rhenium(V) Complexes Stabilized by a Monoanionic Cyclen Ligand, European Journal of Inorg. Chem. (2004) 243. (cover picture)
  • F. Marques, K. P. Guerra, L. Gano, J. Costa, M. P. Campello, L. M. P. Lima, R. Delgado, I. Santos, 153Sm and 166Ho Complexes with Tetraaza Macrocycles Containing Pyridine and Methylcarboxylate or Methylphosphonate Pendant Arms, J. of Biological Inorganic Chemistry 9 (2004) 859.
  • T. Kniess, J. D. G. Correia, Â. Domingos, E. Palma, I. Santos,  Synthesis and Structural Characterization of Novel Re(I) Tricarbonyl Complexes Anchored on a Phosphinoarylbenzylamine and a Phosphinoaryl-oxazoline Generated in situ, Inorg. Chem. 42 (2003) 6130.
  • R. Garcia, A. Paulo, A. Domingos, I. Santos, Reactivity of [Re{k3-H(m-H)B(timMe)2}(CO)3] towards neutral substrates,  Inorg. Chem. 41 (2002) 2422.
  • Garcia, R., Paulo, A., Domingos, A., Santos, I., Ortner, K., Alberto, R., Re and Tc Complexes Containing B-H…M Agostic Interactions as Building Blocks for the Design of Radiopharmaceuticals, J. Am. Chem. Soc. 122 (2000) 11240.