Curriculum Vitae

Centro de Ciências e Tecnologias Nucleares (C2TN)


Name: Maria Cristina
Surnames: das Neves Oliveira
Born: 14-02-1958, Coimbra, Portugal
Nationality: Portuguese

Phone: +351-21 994 6195
Fax: +351 21 994 6185
E-mail: cmelo (add@itn.pt)


Education

  • 2000 – Public defense of a dissertation to get researcher degree, ITN.
  • 1982 – Graduation in Chemical Engineering, Faculty of Science and Technology, University of Coimbra.

Professional Employment Career

  • Since 2000 – Researcher, Instituto Tecnológico e Nuclear (ITN).
  • 1990-2000 – Research Assistant, Instituto Tecnológico e Nuclear (ITN).
  • 1985-1990 – Research Trainee, Department of Radioisotopes (LNETI).

Fellowships and Training

  • Synthesis of b-halo tamoxifen derivatives, Centro de Química Estrutural, IST (2000-2002).
  • Study of novel routes for the synthesis of 7a-substituted estrones, Institute of Advanced Material Study, Kyushu University, Japan (1998).
  • Synthesis of h6-dehydroestrone-tricarbonylchromium complexes as precursors for 7a-substituted alkylestratrienes, Organic Chemistry Institute, Hannover University, Germany (1997).
  • Synthesis of steroid derivatives, Laboratório de Química Farmacêutica, Universidade de Coimbra (1995-1997).
  • IAEA fellowship at NETRIA (St. Bartholomew's Hospital, London) on the radioiodination and radioimmunoassay of steroid hormones (1992).
  • IAEA fellowship at the Institute of Isotopes (Hungarian Academy of Sciences, Budapest) on the radioiodination and radioimmunoassay of steroid and thyroid hormones (1990).

Main Scientific Areas of Research

  • The main scientific area of research is in Organic Chemistry namely in the development of novel synthetic routes for the preparation of steroid based radiopharmaceuticals with potential application in oncology.
  • Cristina has also been involved in the preparation of 125I-labelled radiopharmaceuticals and has devoted special attention to study the chemical structure/ biological activity relationship of estrogen receptor ligands for diagnosis and/ or therapy of human breast tumours.

Other Scientific Areas of Interest

  • High Pressure Liquid Chromatography. In vitro and in vivo biological assays. Radioimmunoassay of Serum Hormones.

Participation in Projects

  • PRAXIS/PSAU/C/SAU/89/96: 17a-[125I] Iodovinylsteroids Substituted at 7a: Investigation of a New Series of Iodine [125I]-Labelled Estrogens as Potential Imaging Agents for Estrogen Receptor-Positive Breast Cancers, (1997–1999).
  • POCTI/33544/QUI/2000: Evaluation of the Genotoxic and Antiestrogenic Potential of Triphenylethylene Derivatives and their Metabolites (2001-2004).
  • CIMAGO/FLAD/09/05: Novel estrogen receptor ligands as potential probes for targeted tumour imaging and therapy (2005-.....).

Scientific Work

  • Monograph "CCMO-histamina-125I - Síntese e Caracterização do Antigénio para Doseamento Radioimunológico do Cortisol no Soro", Sacavém (1988).
  • Monograph "Hormonas Esteróides Sexuais – Anticorpos e Antigénios Iodados Utilizados em Doseamento Radioimunológico", Sacavém (1988).
  • Monograph "Steroid Receptor-Based Radiotracers for Imaging Breast Tumours", Sacavém (1999).
  • Dissertation "Potential Imaging Agents for Estrogen Receptor-Positive Breast Tumours – Synthesis and Characterisation of Estrogen Derivatives", Sacavém (1999).
  • Original Publications in Refereed Journals and Proceedings of International Conferences (11).
  • 32 Communications to National and International Meetings (9 oral presentations).

Selected Publications

  • M. Kuchar, M. C. Oliveira, L. Gano, I. Santos, T. Kniess, Radioiodinated sunitinib as a potential radiotracer for imaging angionesis-radiosynthesis and first radiopharmacological evaluation of 5-[125I]iodo-sunitinib, Bioorganic & Medicinal Chemistry Letters, 22, 2850-2855 (2012).
    Journal impact factor: 2.338, Citations: 2.
  • C. Neto, M. C. Oliveira, L. Gano, F. Marques, T. Thiemann, I. Santos, Novel estradiol based complexes of Tc-99m, Journal of Inorganic Biochemistry, 111, 1-9 (2012).
    Journal impact factor: 3.197, Citations: 1.
  • C. Neto, C. Fernandes, M.C. Oliveira, L. Gano, F. Mendes, T. Kniess, I. Santos, Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents, Nuclear Medicine & Biology, 39, 247–260 (2012). Journal impact factor: 2.517, Citations: 0.
  • M. Morais, P. D. Raposinho, M. C. Oliveira, D. Pantoja-Uceda, M. A. Jimenez, I. Santos, J. D. G. Correia, NMR Structural Analysis of MC1R-Targeted Rhenium(I) Metallopeptides and Biological Evaluation of 99mTc(I) Congeners, Organometallics, 31, 5929-5939 (2012).
    Journal impact factor: 4.145, Citations: 1.

Other publications

  • G. R. Morais, N. Yoshioka, M. Watanabe, S. Mataka, M. C. Oliveira, T. Thiemann, C7-substituted Estranes and Related Steroids, Mini-Reviews in Organic Chem. 3, 229-251 (2006).
  • G. R. Morais, M. C. Oliveira, T. Thiemann, Synthesis of C7-substituted Estra-1,3,5(10),6-tetraen-3,17β-diols, Lett. Org. Chem. 3, 214-270 (2006).
  • M.C. Oliveira, M. Videira, A. Almeida, L. Gano, M. Watanabe, T. Thiemann, A.C. Santos, F. Botelho, C. Oliveira, Synthesis and Biodistribution Studies of Two Novel Radioiodinated areno-annelated estra-1,3,5(10),6-tetraene-3-ols as Promising Estrogen Receptor Radiologands, J Label Compd Radiopharm. 49, 559-569 (2006).
  • K.G. Dongol, M.C. Melo e Silva, K. Matsubara, T. Matsumoto, S. Mataka, T. Thiemann, p-facial Selectivity in the Formation of Tricarbonylchromium(0) Complexes of Estra-1,3,5(10),6-tetraenes, Z. Anorg. Allg. Chem., 629:945-947 (2003).
  • J. Wang, M. Watanabe, S. Mataka, T. Thiemann, G.R. Morais, E.T. Silva, M.C. Melo e Silva, Synthesis and Radiosynthesis of 17α-[p-(Iodophenylethynyl)]estra-3,17β-diols, Naturfor schg., Sect B 58:799-804 (2003).
  • M.C. Melo e Silva, L. Patrício, L. Gano, M. L. Sá e Melo, E. Inohae, S. Mataka. T. Thiemann, Synthesis and Biological Evaluation of Two New Radiolabelled Estrogens, (17a,20E)- and (17a,20Z)-21-[ 125I] Iodo-19-Norpregna-1,3,5(10),6,20- Pentaene-3,17b-Diol-3-(Methyl ether), Appl Radiat Isot. 54:227-239  (2001).