Curriculum Vitae

Centro de Ciências e Tecnologias Nucleares (C2TN)


Name: Célia Maria
Surnames: da Cruz Fernandes
Born: 28-07-1961, Fajão, Portugal
Nationality: Portuguese

Phone: +351-21-994 6226
Fax: +351 21 994 6185
E-mail: celiaf (add @itn.pt)


Education

  • 2009 – PhD in Pharmaceutical Chemistry (Pharmacy), Faculty of Pharmacy, University of Lisbon.
  • 1999 – MSc in Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lisbon.
  • 1991 – Graduate in Chemical Engineering, Instituto Superior de Engenharia de Lisboa.
  • 1984 – BSc in Chemical Engineering, Instituto Superior de Engenharia de Lisboa.

Professional Employment Career

  • Since 2013 – Auxiliary Researcher, Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Bobadela, Portugal.
  • Since 2009 - Auxiliary Researcher in the Radiopharmaceutical Sciences Group, Chemical and Radiopharmaceutical Sciences Unit, ITN.
  • 1995-1999 – Research Assistant, Instituto Tecnológico e Nuclear (ITN).
  • 1999-2009 – Research Trainee, Instituto Tecnológico e Nuclear (ITN).
  • 1990-1995 – Technician, Instituto Tecnológico e Nuclear (ITN).
  • 1986-1990 – Fellowship, Instituto Nacional de Engenharia e Tecnologia Industrial (INETI).

Fellowships and Training

  • 25/02-22/03/2002 – ICCTI/DAAD Fellowship, Forschunszentrum Rossendorf, Institut fur Bioanorganische und Radiopharmazeutische Chemie, Germany, in the group of Doctor Hartmut Spies.
  • 06/08-06/09/2001 – ICCTI/DAAD Fellowship, Forschunszentrum Rossendorf, Institut fur Bioanorganische und Radiopharmazeutische Chemie, Germany.
  • 02/05-02/06/2000 – Training at the Forschunszentrum Rossendorf, Institut fur Bioanorganische und Radiopharmazeutische Chemie, Germany. STSM (Short-Term Cientific Mission). COST ACTION B12, Radiotracers for in vivo Assessment of Biological Functions, WG 5: TECHNETIUM CHELATES.
  • 1986-1990 – INETI/ICEN fellowship at Departamento de Radioisótopos of Instituto Ciência e Engenharia Nuclear (ICEN).

Membership of Professional Societies

  • Member of the Sociedade Portuguesa de Medicina Nuclear.

Scientific Specialization

  • Molecular imaging and radiopharmaceutical sciences.

Main Scientific Areas of Research

  • Medicinal Chemistry.
  • Radiochemistry and Radiopharmacy.

Scientific Works

  • PhD Thesis "Complexos de Re e Tc e Compostos Iodados Relevantes para a Concepção de Radiofármacos", Faculdade de Farmácia, Universidade de Lisboa, 2009.
  • MSc Theses "Complexos de 99mTc com Aminoácidos e Dipéptidos", Faculdade de Farmácia, Universidade de Lisboa, 1999."
  • Monograph "Radiofármacos Halogenados para o Estudo dos Receptores Dopaminérgicos por PET e SPECT", Faculdade de Farmácia, Universidade de Lisboa, 1999.
  • 18 original publications in international refereed journals.
  • 16 published proceedings and abstracts of national and international conferences.
  • 15 oral communications in national and international meetings (2 invited).
  • 50 poster communications in national and international meetings.

Prizes

  • Prize Nycomed Amersham for the best poster in "VII Congresso Nacional de Medicina Nuclear", Sintra, 1998.
  • POSTER PRIZE in the session "Chemistry of Technetium and other metals" in 6th International Symposium on Technetium in Chemistry and Nuclear Medicine, Italy, September, 2002.

 Participation in Projects

  • Principal Investigator: EXPL/QEQ-MED/1950/2013 - Dual Targeting Strategy for EGFR Positive Tumors. April 2014– April 2015, Funded by FCT.
  • Team Member: EXCL/QEQ-MED/0233/2012 - Molecular and Nano Tools for Cancer Theranostics. June 2013 - June 2018, Funded by FCT.
  • Team Member: PTDC/SAU-FAR/115846/2009 - Albumin binding-domain fusions to improve protein pharmacokinetics. March 2011- March 2014, Funded by FCT.
  • Team Member: PTDC/QUI-QUI/111891/2009 - Synthesis and Pre-clinical Evaluation of Novel Estradiol-Based Indium Complexes for Targeted Radiotherapy of Tumors. April 2011- April 2014, Funded by FCT.
  • Colaboration in the project "Synthesis, Characterization and Biological Assessment of Multi-Functional Bone-Seeking Agents". PTDC/QUI-QUI/111891/2009. March 2011- March 2014.
  • Participation in the project on Tc-99m complexes for myocardial imaging within a Research Contract/Tyco/Healthcare, 2006-2008.
  • COST Action “Radiotracers for in vivo Assessment of Biological Functions”. Funding: Action COST B12 (1999- 2004).

Selected Publications

  • D. Can, B. Spingler, P. Schmutz, F. Mendes, P. Raposinho, C. Fernandes, F. Carta, A. Innocenti, I. Santos, C.T. Supuran, R. Alberto. [(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX. Angew Chem Int Ed 2012, 51, 3354-3357.Journal impact factor:  13.743, Citations: 12.
  • Carina Neto, Célia Fernandes, Maria Cristina Oliveira, Lurdes Gano, Filipa Mendes, Torsten Kniess, Isabel Santos. Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents. Nucl Med Biol, 2012, 39; 247-260.
    Journal impact factor: 2.517, Citations:  0.
  • Leonor Maria, Célia Fernandes, Raquel Garcia, Lurdes Gano, António Paulo, Isabel Cordeiro dos Santos, Isabel Santos. Tris(pyrazolyl)methane 99mTc tricarbonyl complexes for myocardial imaging. Dalton Trans., 2009, 603-609.Journal impact factor: 4.081, Citations:  1.
  • C. Fernandes, I. C. Santos, I. Santos, H-J. Pietzsch, J-U. Kunstler, W. Kraus, A. Rey, N. Margaritis, A. Bourkoula, A. Chiotellis, M. Paravatou-Petsotase, I. Pirmettis. Rhenium and technetium complexes bearing quinazoline derivatives: progress towards a 99mTc biomarker for EGFR-TK imaging. Dalton Trans., 2008, 3215–3225.
    Journal impact factor: 3.580, Citations:  22.

Other Publications

  • Filipa Mendes, Lurdes Gano, Célia Fernandes, António Paulo, Isabel Santos. Studies of the myocardial uptake and excretion mechanisms of a novel 99mTc heart perfusion agent. Nucl Med Biol, 2012, 39; 207-213.
    Journal impact factor: 2.517, Citations: 2.
  • L. R. Goethals, I. Santos, V. Caveliers, A. Paulo, F. De Geeter, L. Gano, C. Fernandes, T. Lahoutte, Rapid hepatic clearance of (99m)Tc-TMEOP: a new candidate for myocardial perfusion imaging, Contrast Media Mol. Imaging, 2011. 6, 178-188.
    Journal impact factor: 3.328, Citations: 4.
  • Harmel W. Peindy N'Dongo, Paula D. Raposinho, Célia Fernandes, Isabel Santos, Daniel Can, Paul Schmutz, Bernhard Spingler, Roger Alberto. Preparation and biological evaluation of cyclopentadienyl-based 99mTc-complexes [(Cp-R)99mTc(CO)3] mimicking benzamides for malignant melanoma targeting. Nucl Med Biol, 2010, 37, 255-264.
    Journal impact factor: 2.62, Citations: 13.
  • Carolina Moura, Célia Fernandes, Lurdes Gano, António Paulo, Isabel C. Santos, Isabel Santos, Maria José Calhorda. Influence of the Ligand Donor Atoms on the in vitro Stability of Rhenium(I) and Technetium (I)-99m Complexes with Pyrazole-containing Chelators: Experimental and DFT Studies. Journal of Organometallic Chemistry, 2009, 694, 950-958.
    Journal impact factor: 2.347, Citations: 9.
  • C. Fernandes, M. C. Oliveira, L. Gano, A. Bourkoula, I. Pirmettis, I. Santos. Radioiodination of New EGFR Inhibitors as Potential SPECT Agents for Molecular Imaging of Breast Cancer. Bioorg Med Chem., 2007, 15: 3974-3980.
    Journal impact factor: 2.903, Citations: 16.
  • C. Fernandes, J. D. G. Correia, L. Gano, I. Santos, S. Seifert, R. Syhre, R. Bergmann, H. Spies. Dramatic Effect of the Tridentate Ligand on the Stability of 99mTc "3+1" Oxo Complexes Bearing Arylpiperazine Derivatives. Bioconjugate Chem, 2005, 16; 660-668.
    Journal impact factor: 4.580, Citations: 16.