Curriculum Vitae

Centro de Ciências e Tecnologias Nucleares (C2TN)


Name: António Manuel
Surnames: Rocha Paulo
Born: 3-06-1962, Bencatel, Portugal
Nationality: Portuguese

Phone: +351-21 994 6196
Fax: +351-21 994 6016
E-mail: apaulo (add @ctn.ist.utl.pt)

ResearcherID is: J-6069-2013
ORCID:
000-0002-9164-0913


Education

  • 1998 – PhD in Chemistry at Instituto Superior Técnico (IST) of the Technical University of Lisbon, with Doctor Isabel Rego dos Santos.
  • 1986 – Graduate in Chemical Engineering, Instituto Superior Técnico (IST) of the Technical University of Lisbon.

Professional Employment Career

  • 02/2006 – Principal Researcher, ITN.
  • Since 1998 – Auxiliary Researcher, ITN.
  • 1992-1998 – Research Assistant, ITN.
  • 1989-1992 – Research Trainee, Instituto Tecnológico e Nuclear (ITN), Sacavém, Portugal.

Fellowships and Training

  • 10/03-16/03/1995 – Easter School on Radiopharmaceuticals, Liverpool/ England.
  • 01/02-30/09/1991 – Training at the Institut für Heisse Chemie, with Professor Basil Kanellakopulos.
  • 1986-1988  – INETI/ICEN fellowship: Departamento de Radioisótopos of Instituto Ciência e Energia Nuclear (ICEN), with Doctor Maria dos Anjos Neves.

Membership of Professional Societies

  • Member of the Sociedade Portuguesa de Química.

Scientific Specialization

  • Inorganic and Organometallic Chemistry.

Other Scientific Areas of Research

  • Radiopharmaceutical Development.

Teaching Activities

  • Since 2009 – Teaching Radiochemistry Chemistry in the Master Course of Medicinal and Therapeutic Chemistry, FF/UL.
  • Since 2000 – Teaching Radiopharmacy in the Technical Nuclear Medicine Course, ESTeSL-Lisbon.

Participation in Projects

  • "Novel Radioactive Probes for Molecular Imaging of Sigma Receptors" (POCI/QUI/59588/2004), since October 2005.
  • "Rhenium Complexes with Nitrogen Donor Ligands: Synthesis, Characterization and Catalytic Studies " (Praxis/C/QUI/10047/1998).
  • "Development of new radiotracers for the in vivo assessment of biological functions and drug interactions" (COST Action B12, 1999-2004).
  • "Development of new radiotracers for the in vivo assessment of biological functions and drug interactions" (COST Action B12, 1999-2005).
  • "Organometallic Rhenium and Technetium Complexes: Design of Radiopharmaceuticals for Brain Receptor Imaging" (POCTI/2001/QUI/42939), March 2002-February 2005.
  • "Multicomponent Technetium and Gallium Metallointercalators for Targeted Radiotherapy" (POCI/QUI/57632/2004), since October 2005.
  • Research Contract/Tyco/Healthcare, 2003-2006.
  • Research Contract/Tyco/Healthcare, 2006-2008.
  • "Inibição da Telomerase como alvo de novos complexos de Cu(II) anti-tumorais" (PTDC/QUI-QUI/114139/2009), since March 2011.
  • "Bimodal Pet-Mri Molecular Imaging Technologies And Applications For In Vivo Monitoring Of Disease And Biological Processes" (COST Action TD1007), since June 2011.
  • "Functional Metal Complexes that Bind to Biomolecules" (COST Action CM1105), since May 2012.
  • "Molecular and Nano Tools for Cancer Theranostics" (EXCL/QEQ-MED/0233/2012), starting in March 2013.

Scientific Works

  • PhD Theses "Oxo-Complexos e Polihidretos de Rénio com Boratos Poli(pirazolilo)", IST-UTL (1998).
  • Monograph "Química de Radiofármacos: A- Monofosfonatos de tecnécio (99mTc/99Tc); B- Marcação de MIBG com 131I na forma de kit liofilizado", LNETI-Sacavém (1991).
  • Monograph "Química de Tecnécio: Aspectos relevantes em radiofármacos", LNETI-Sacavém (1991).
  • 68 Original Publications in Refereed Journals.
  • 68 Communications to National and International Meetings.

4 Selected Publications

  • Zambre, A. , Silva, F., Upendran, A.; Afrasiabi, Z; Xin, Y. ; Paulo, A.; Kannan, R. ; Synthesis and Characterization of Functional Multicomponent Nanosized Gallium Chelated Gold Crystals, Chem. Commun. (2014), in press, DOI: 10.1039/C3CC47308B.
    Journal Impact Factor: 6.378
  • Esteves, T; Marques, F; Paulo, A; Rino, J; Nanda, P; Smith, CJ; Santos, I; Nuclear targeting with cell-specific multifunctional tricarbonyl M(I) (M is Re, Tc-99m) complexes: synthesis, characterization, and cell studies, J. BIOL. INORG. CHEM. (2011), 16, 1141-1153.
    Times Cited: 7; IF: 3,289
  • Maria, L; Fernandes, C; Garcia, R; Gano, L; Paulo, A; Santos, IC; Santos, I; Tris(pyrazolyl)methane Tc-99m tricarbonyl complexes for myocardial imaging , DALTON TRANSACTIONS (2009), 603-606.
    Times Cited: 13, IF: 4,081
  • Vitor, RF; Correia, I; Videira, M; Marques, F; Paulo, A; Pessoa, JC; Viola, G; et al., Pyrazolyl-diamine ligands that bear anthracenyl moieties and their rhenium(I) tricarbonyl complexes: Synthesis, characterisation and DNA-binding properties, CHEMBIOCHEM (2008), 9, 131.
    Times Cited: 19, IF: 3,322

Other Publications

  • A. Paulo, I. Santos, New tridentate chelators of the type tris(pyrazolyl)methane, and bis(pyrazolyl)amine for preparing a tricarbonyl complex a radioisotope of technetium useful for preparing myocardial imaging composition, US2013131327-A1.
  • L. Maria, C. Fernandes, R. Garcia, L. Gano, A. Paulo, I. C. Santos, Isabel Santos, Tris(pyrazolyl)methane 99mTc tricarbonyl complexes for myocardial imaging, Dalton Trans., 2009, 603–606.
  • R. F. Vitor, I. Correia, M. Videira, F. Marques, A. Paulo, J, C. Pessoa, G. Viola, G. G. Martins, I. Santos, Pyrazolyl-Diamine Ligands That Bear Anthracenyl Moieties and Their Rhenium(I) Tricarbonyl Complexes: Synthesis, Characterization and DNA-Binding Properties, ChemBioChem 2008, 9 (1) 131-142.
  • L. Maria, A. Paulo, I. C. Santos, I. Santos, P. Kurz, B. Spingler, R. Alberto, Very Small and Soft Scorpionates: Water Stable Technetium Tricarbonyl Complexes Combining a Bis-agostic (k3-H, H, S) Binding Motif with Pendant and Integrated Bioactive Molecules, J. Am. Chem. Soc. 2006, 128, 14590-14598
  • R. Garcia, L. Gano, L. Maria, A. Paulo, Isabel Santos e H. Spies, Synthesis and Biological Evaluation of Tricarbonyl Re(I) and Tc(I) Complexes Anchored by Poly(azolyl)borates: Application on the Design of Radiopharmaceuticals for the Targeting of 5-HT1A Receptors, J. Biol. Inorg. Chem. 2006, 11, 769-782.
  • S. Alves, J. D. G. Correia, A. Paulo, L. Gano, J. Smith e I. Santos, Pyrazolyl Containing Ligands as Bifunctional Chelators for Labelling Biomolecules with the fac-[M(CO)3]+ Moiety (M=99mTc, Re): Synthesis, Characterization and Biological Behaviour, Bioconjugate Chemistry 2005, 16, 438-449.