Curriculum Vitae

Institute for Biotechnology and Bioengineering (IBB - Laboratório Associado)


Photo.

Name: Maria Teresa Ferreira Marques
Surnames: Pinheiro
Born: 23/07/1960, Lisbon, Portugal
Nationality: Portuguese

Tel.: (+351) 21-994 6250
Fax: (+351) 21-994 6285
E-mail: murmur (add @ctn.tecnico.ulisboa.pt)


Education

  • 1995 – Ph.D., Faculdade de Ciências de Lisboa, Lisbon, Portugal.

Professional Employment Career

Fellowships and Training

  • 1989-1992 – Research fellowship, European Commission, Joint Research Centre, IRMM, Geel, Belgium.

Scientific Specialization

  • Physiology of trace elements.
  • Morphological and elemental characterization of cells and tissues with nuclear and X-ray microscopy techniques, using particle accelerators and synchrotrons.

Main Interests and Activities

  • Biomedicine; physiology; microscopy based on accelerated particles and synchrotron radiation.
  • Inflammatory and oxidative processes in chronic human pathologies. Association of imaging and elemental micro-analytical techniques and molecular techniques to the study of physiological processes in cells and tissues.

Membership of Professional Societies

  • Since 2002 – Member of the International Committee of the ICNMTA conference (International Conference on Nuclear Microprobe Technology and Applications). Technical Internal Auditing to methodologies for water and waste water analysis by Total Reflection X-ray Fluorescence (certified laboratory LAACQ/INETI.

Teaching Activities

  • 2003-2008 – Supervision of Ph.D. and M.Sc. thesis.
  • 1996-2008 – Supervision and shared supervision of graduation Theses (BSC, MSc or PhD) in Environmental Engineering (UNL), Chemistry (FC-UL), Physics (UNL) and Biology (FC-UL) fields of science.

Participation in Projects

COORDINATION

  • Liga dos Amigos do Hospital de Sta Marta (2008-  ):  Vascular apoptosis and plaque composition evaluated with IVUS VH. Lisbon Central Hospital- Hosp. Sta Marta/EP - Serviço de Cardiologia/ITN / CBA - FCUL.
  • EC/QLKT-CT-2002-02678 - NANODERM: Quality of skin as a barrier to ultra-fine particles, (2003-2007). Consortium: Germany, France, Hungary, Belgium, Sweden, Poland and Portugal.
  • IAEA RC 302-F1.20.19-POR-13262 (2005-2007): Nuclear Microprobe Analysis of Human Skin Applied to the Study of Haemochromatosis. ITN / Hospital Sta Maria/ Faculty of Medicine -UL/INETI.
  • LS2112/2001 (2001) European Commission – ESRF, European Synchrotron Research Facility, Mobilisation of Ni and toxic elements in the human respiratory system. ITN, INETI, ESRF.

PARTICIPATION

  • PTDC/AMB/65828/2006 (2007-2010):  Exhaled breath condensate: A tool for noninvasive evaluation of pollutant exposition? Instituto de Soldadura e Qualidade (ISQ)/ITN / Hospital de Santa Maria.
  • Liga dos Amigos do Hospital de Sta Marta (2006-2008): Evaluation of systemic markers and cell activation markers in the acute myocardial infarction. Hospital de Sta Marta/MS - Serviço de Cardiologia/ ITN / CBA - FCUL.
  • Liga dos Amigos do Hospital de Sta Marta (2006-2008): Oxidative Stress and Systemic Markers Evaluation in Cardiac Failure. Hospital de Sta Marta/MS - Serviço de Cardiologia/ ITN / CBA - FCUL.
  • Fundacion Salud 2000 (2006-2008): T-cell subsets modulation in psoriatic lesions by photo(chemo)therapy and systemic biological agents. Hospital de Santa Maria - Clínica Universitária de Dermatologia Maria / ITN.
  • Programa de Re-equipamento Científico (2005): CISTER, Centre for Isotopes and Trace Elements Research.
  • SPDV-Sociedade Portuguesa de Dermatologia e Venereologia (2004/2008): A Pele como orgão de monitorização da acumulação de Ferro na hemocromatose. Hospital de Santa Maria - Serviços de Dermatologia e Imunohemoterapia / ITN.
  • FCT/POCTI/ESP/41008 (2002-2005): Markers of the prooxidant/antioxidant balance and characterisation of the allelic profile of apoE in inhabitants of Lisbon and Ponta Delgada. Centro de Biologia Ambiental e Centro de Química e Bioquímica /Fundação da Faculdade de Ciências, Universidade de Lisboa, Centro de Investigação de Recursos Naturais, Universidade dos Açores, INSA Doutor Ricardo Jorge, ITN.
  • FCG/SDH.IC.I.01.22 (2001-2004): Contribuição para o estudo de bioindicadores da inflamação na Doença Pulmonar Obstrutiva Crónica - DPOC. Associação para a Investigação e o Desenvolvimento da Faculdade de Medicina, Serviço de Pneumologia, HSM, Centro de Biologia Ambiental e Centro de Química e Bioquímica /Fundação da Faculdade de Ciências, ITN.
  • FCT/POCTI/BFE/3991 (2002-2005): Biovailability of lead in small mammals at a mine contaminated area in Alentejo (Central Portugal). Centro de Biologia Ambiental e Centro de Química e Bioquímica /Fundação da Faculdade de Ciências,Universidade de Lisboa / ITN.
  • CORRAM-PRAXIS/POCTI/CTA/1707/95: Octopod cephalopods: relation of the resources with the marine environment. Faculdade de Ciências da Universidade de Lisboa, DOP – Universidade dos Açores, UCTRA – Universidade do Algarve, Universidade Aberta / ITN.
  • European Commission, Large Scale Facilities Access, LURE, TMR 900-98, (1997-1999): Microanalysis of Toxic Elements in Human Teeth by SRXRF. ITN / Centro de Física Atómica da Universidade de Lisboa / Faculdade de Medicina Dentária da Universidade de Lisboa.
  • PRAXIS/PSAU/C/SAU/120/96 (1997-1999): Irradiação de implantes de biomateriais para doentes oncológicos de cabeça e pescoço. Instituto Português de Oncologia, ITN.
  • JNICT/DGA, PEAM/P/NMA/666/95 (1996-2000): Pesquisa de parâmetros indicadores de ecotoxicidade em comunidades aquáticas e ripícolas do Guadiana. Centro de Biologia Ambiental e Centro de Química e Bioquímica /Fundação da Faculdade de Ciências,Universidade de Lisboa, ITN.
  • JNICT/DGA, PEAM/P/GAG/226/93 (1996-1998): Poluição por elementos metálicos na Bacia do Trancão – Solos, Sedimentos e Recursos Hídricos, ITN.

Prizes or Awards

  • 1996 – Research carried out :Tratamento crónico com compostos de alumínio. Risco de toxicidade? Sociedade Portuguesa de Gastroenterologia.
  • 2005 – Best Poster TEMA12: Trace Elements in Man and Animals. Scientific developments, novel applications and progress.
  • 2003 – Best Poster 4th. International Symposium on Trace Elements in Humans.
  • 2005 – Researh Grant: Bolsa Serono de Investigação Serono - Fundacion Salud 2000.

Scientific Work

  • Ph.D. Thesis: Biologia dos Elementos Vestigiais na Aterosclerose, Universidade de Lisboa, Portugal, 1995).
  • Chapters in books: T. Pinheiro, M.D. Ynsa and L.C. Alves. Imaging biological structures with proton microprobe. In Modern Research and Educational Topics in Microscopy, Microscopy series Nº3, Vol. 1, Ed. A. Mendez-Vilas and J. Diaz (Formatex, Badajoz, Spain) pp. 237.
  • More than 59 papers in international scientific periodicals with referees.
  • More than 35 papers in conference proceedings.
  • More than 17 oral communications by invitation.

5 Relevant Publications

  • Napoleão P, Santos MC, Selas M, Cruz Ferreira R, Viegas-Crespo AM, Pinheiro T. Inflammatory indicators in the evolution of acute myocardial infarction. Inflammation Research, 2007; 56 (Suppl 2): S107 – A88.
  • C.C. Marques, S.I. Gabriel, T. Pinheiro, A.M. Viegas-Crespo, M.L. Mathias, M.J. Bebianno. Metallothionein levels in Algerian mice (Mus spretus) exposed to elemental pollution: an ecophysiological approach. Chemosphere 71;2008:1340-1347.
  • P. Napoleão, M.C. Santos, M. Selas, R. Cruz Ferreira, A.M. Viegas-Crespo, T. Pinheiro. Inflammatory indicators in the evolution of acute myocardial infarction (2007). Inflammation Research, 56 (Suppl 2): S107 – A88.
  • P. Napoleão, R. Cruz Ferreira, M. Selas, A. Turkman, V. Andreozzi, T. Pinheiro, A.M. Viegas-Crespo. CLINICAL SIGNIFICANCE OF SERIAL CHANGES OF OXIDIZED LOW DENSITY LIPOPROTEIN IN ACUTE MYOCARDIAL INFARCTION. Atherosclerosis.
  • P. Napoleão, A.Toste, M. Selas, A. Turkman, V. Andreozzi, A.M. Viegas-Crespo, R. Cruz Ferreira, T. Pinheiro, Inflammatory responsiveness in the acute myocardial infarction, Inflamm. Res.
  • P. Filipe, J.N. Silva, R. Silva, J.L. Cirne de Castro, M. Marques Gomes, L.C. Alves, R. Santus, T. Pinheiro, Skin permeability to TiO2 and ZnO nanoparticles versus the stratum corneum barrier dogma, Skin Res. Technol.